Creatine has been thought of as synonymous with other performance enhancing drugs such as: android, anadrol, anabolic steroids, testosterone, human growth hormone, and such. Creatine is primarily used as a weight lifting supplement. To put creatine in the same category as these other performance enhancing drugs is to show how uneducated you are on exactly what it is that creatine is and tries to accomplish.
Creatine is a natural component of skeletal muscle. It is produced in synthesis in smaller amount through our natural diets, usually stemming from meats that carnivorous animals acquire through their natural diets. This is a product we intake whether we like to or not, and as it is a natural substance takin in by our bodies, I already have shown it to be a quality supplement, if taken in correct doses.
Simply speaking, creatine is a supplement which causes and increase in our muscle energy availability stores. The cells of our body store their energy in the form of a molecule known as Adenosine TriPhohsphate, or ATP. The amount of work our muscles can perform is a direct consequence of the amount of ATP they have stored as well as the ease with which ATP is regenerated with the help of PCr during strenuous exercise. Think of ATP as the cell's energy currency and phosphocreatine as a debit card with an adjustable balance - the balance being set by creatine deposit via the diet.
First and foremost, creatine enhances physical performance by increasing the number of times that ATP can be recycled during physical exertion without increasing the absolute amount of ATP stored within our muscles. In the short-term this means that creatine supplementation should improve our ability to sustain near maximal force generation during repetitive bouts of intense exercise without actually increasing the amount of peak force we can produce.
Creatine is transferred into our skeletal muscles in an inward basis. That is, the sodium levels on the inside of the living cells is greater than that of the sodium content on the outside of the cells. During your taking of creatine, eating highly glycemic foods will increase insulin injection and will help sort of soak up the creatine into your skeletal muscles much more easily.
The activity of these creatine transporters is also influenced by the presence of creatine itself in the following manners:
(1) elevated plasma creatine interrupts creatine uptake into skeletal muscle via these transporters;
(2) the synthesis of creatine from amino acids is also stopped by elevated plasma creatine.
These are nothing more than examples of normal regulatory feedback processes that are common in cell biology. However, how exogenous creatine supplementation influences these processes in humans is still an open issue. This is why it is often recommended to periodically stop taking creatine to let the body recuperate. Omitting the load phase from supplementation will also mitigate this drawback of creatine supplementation.
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